Monitor and adjust transmembrane pressure (TMP) cutoff ，membrane area，shear force  and cross flow rate to optimize  phage product yield.

Optimize buffer system to maximize phage recovery yield and stability.

Enhance purity and recovery

In-house column packing and qualification

Resin screening and selection

Column cycling and aging studies

Reduction of process residuals

Cryoprotectant and excipient screening to enhance the stability of phage product.

Stability studies and testing.